CAVATAK (Coxsackievirus A21) displays potent oncolytic activity in BRAFV600E mutant melanoma cells resistant to selective BRAF kinase inhibitors

Title: CAVATAK (Coxsackievirus A21) displays potent oncolytic activity in BRAFV600E mutant melanoma cells resistant to selective BRAF kinase inhibitors
Creator: Shafren, D. R.; Farrelly, M.; Croft, A. J.; Davies, B.; Stewart, J.; Ingham, R.; Quah, M. Y.; Au, G.; Hersey, P.
Relation: 2011 International Melanoma Congress. Pigment Cell & Melanoma Research (Tampa, FL 9-13 November, 2011) p. 1047
Publisher Link: http://dx.doi.org/10.1111/j.1755-148X.2011.00909.x
Publisher: Wiley-Blackwell Publishing
Resource Type: conference paper
Date: 2011
Description: CAVATAKTM is a naturally occurring Picornavirus, which induces mild upper respiratory symptoms during natural infection of humans. CAVATAKTM also displays potent oncolytic activity against both in vitro cultures of human cancer cells and against in vivo xenografts of human cancers in mouse models of melanoma, prostate cancer, breast cancer and multiple myeloma, all which exhibit high surface intercellular adhesion molecule-1 (ICAM-1) expression. Overall, these preliminary findings suggest that systematic melanoma treatment regimes including both vemurafenib and CAVATAKTM may have favourable clinical outcomes and as such deserve further evaluation.
Subject: picornavirus; oncolytic; cancer cells; melanoma; prostrate; myeloma
Identifier: http://hdl.handle.net/1959.13/1036304
Identifier: uon:13251
Identifier: ISSN:1755-148X
Language: eng

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